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KMID : 0545120100200040803
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Journal of Microbiology and Biotechnology
2010 Volume.20 No. 4 p.803 ~ p.808
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Effects of Ultra High Molecular Weight Poly-γ-glutamic Acid from Bacillus subtilis (chungkookjang) on Corneal Wound Healing
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Bae Sun-Ryang
Park Chung
Choi Jae-Chul
Poo Ha-Ryoung
Kim Chul-Joong
Sung Moon-Hee
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Abstract
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Poly-γ-glutamic acid (γ-PGA) is a natural, edible polypeptide in which glutamate is polymerized via γ-amide linkages. First, we assessed the eye irritancy potential of γ PGA in rabbits. Additionally, we studied the effects of γ-PGA on corneal wound healing, due to the anti inflammatory properties and water retaining abilities of γ-PGA. In this study, the effects of γ-PGA on corneal wound healing after an alkali burn were evaluated. Thirty eyes wounded by alkali burning in 30 white rabbits were divided into three groups: group A was treated with 0.1% 5000 kDa γ-PGA for 2 days, group B was treated with 0.1% hyaluronic acid, and group C was not treated, as a control. The area of corneal epithelial defect was examined at 12, 24, 30, 36, 42, and 48 h after corneal alkali wounding to determine initial wound healing. We found that γ-PGA promoted corneal wound healing, compared with controls, and showed similar effects to hyaluronic acid. These results indicate that γ-PGA stimulates corneal wound healing by an anti inflammatory effect and enhancing cell migration and cell proliferation. γ-PGA is a promising biomaterial that may be a substitute for hyaluronic acid in corneal wound healing treatment.
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KEYWORD
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poly-γ-glutamic acid (γ-PGA), corneal wound healing, hyaluronic acid
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